Web-based bioinformatic tool LYNX: LYmphoid NeXt-generation sequencing data analysis and visualization in hematological malignancies.

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Authors

PORC Jakub Paweł REIGL Tomáš NAVRKALOVÁ Veronika HYNŠT Jakub PÁL Karol STRÁNSKÁ Kamila KOTAŠKOVÁ Jana POSPÍŠILOVÁ Šárka

Year of publication 2023
Type Conference abstract
MU Faculty or unit

Central European Institute of Technology

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Description Next-generation sequencing (NGS) is rapidly advancing technology in cancer genomics. The single NGS experiment can replace several laboratory tests and provide requested information about the tumor samples. However, new requirements for bioinformatic tools and computational resources are emerging in diagnostics and research. Following the development of an integrative, targeted NGS panel LYNX, enabling the detection of genetic markers recurring in lymphoid malignancies (PMID: 34082072), we focused on designing a LYNX bioinformatics tool, featuring all necessary analytical steps as well as a user interface (UI) for easy data representation and interpretation. State-of-the art resources were used to achieve our goal, such as React.js, D3.js visualisation library, Integrated Genome Browser and GATK industry standard variant calling pipeline.
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