Synthesis and Antiviral Activity of 2′-Modified L-Nucleoside Analogues.
| Authors | |
|---|---|
| Year of publication | 2023 |
| Type | Article in Periodical |
| Magazine / Source | ChemistrySelect |
| MU Faculty or unit | |
| Citation | |
| Web | https://chemistry-europe.onlinelibrary.wiley.com/doi/full/10.1002/slct.202303585 |
| Doi | http://dx.doi.org/10.1002/slct.202303585 |
| Keywords | Antiviral Agent; L-2 2'-anhydrouridine; L-Arabinose; Cytotoxicity; L-Nucleoside |
| Description | Nucleoside analogues have been the foundation of antiviral therapy over the past few decades. D-nucleosides with natural stereochemistry occupies the lion share of the marketed antiviral agents. However, much less effort have been put towards the development of L-nucleosides as antiviral agents. Herein, our effort towards the synthesis of 2' -substituted L-nucleoside analogues is reported as an emerging class of antiviral agents. Biological activity of the synthesized L-nucleosided was evaluated against two viruses of importance, tick-borne encephalitis virus (TBEV) and Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) in adenocarcinomic human alveolar basal epithelial cells (A459) and Vero cells. Ring opening of L-2, 2'-Anhydrouridine (2) with various nucleophiles to make several 2‘-substituted L-nucleosides is the key synthetic outcome. This development has paved the way in the synthesis of many new analogues of 2‘-substituted L-nucleosides for numerous applications. |
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