The Effect of CNQX on Self-Administration: Present in Nicotine, Absent in Methamphetamine Model

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Authors	HRICKOVÁ Mária AMCHOVÁ Petra RUDÁ Jana
Year of publication	2024
Type	Article in Periodical
Magazine / Source	FRONTIERS IN BEHAVIORAL NEUROSCIENCE
MU Faculty or unit	Faculty of Medicine
Citation
Web	https://www.frontiersin.org/articles/10.3389/fnbeh.2023.1305412/full
Doi	http://dx.doi.org/10.3389/fnbeh.2023.1305412
Keywords	AMPA/kainate receptor; CNQX; Nicotine; Methamphetamine; Self-administration; Relapse
Description	CNQX significantly reduced nicotine intake during the maintenance phase, but no effect was revealed on nicotine seeking after forced abstinence. CNQX did not affect methamphetamine taking or seeking. The effect of reducing nicotine taking but not seeking could be explained by different involvement of glutamatergic receptors in various stages of nicotine dependence.
Related projects:	Preclinical and clinical research in pharmacokinetics, neuropsychopharmacology and personalized pharmacotherapy in oncology