Strongyloides in non-human primates: significance for public health control

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Authors

NOSKOVÁ Eva SAMBUCCI Kelly Marie SAMBUCCI Kelly Marie ČERVENÁ Barbora PETRŽELKOVÁ Klára PETRŽELKOVÁ Klára ČERVENÁ Barbora MODRÝ David MODRÝ David PAFČO Barbora PAFČO Barbora

Year of publication 2024
Type Article in Periodical
Magazine / Source Philosophical Transactions of the Royal Society B : Biological Sciences
MU Faculty or unit

Faculty of Science

Citation
Web https://royalsocietypublishing.org/doi/full/10.1098/rstb.2023.0006?casa_token=Vi7mJvhtlgsAAAAA%3ApF9AjZ6oBPefkq0YcsTY4dZIhy_90b2n_x8nNS2ydq59yD_FHVfyHK0C7ollL98b8trfZAG9u3JadBHR
Doi http://dx.doi.org/10.1098/rstb.2023.0006
Keywords Strongyloides; primates; microscopy; molecular methods
Description Primates are an important source of infectious disease in humans. Strongyloidiasis affects an estimated 600 million people worldwide, with a global distribution and hotspots of infection in tropical and subtropical regions. Recently added to the list of neglected tropical diseases, global attention has been demanded in the drive for its control. Through a literature review of Strongyloides in humans and non-human primates (NHP), we analysed the most common identification methods and gaps in knowledge about this nematode genus. The rise of molecular-based methods for Strongyloides detection is evident in both humans and NHP and provides an opportunity to analyse all data available from primates. Dogs were also included as an important host species of Strongyloides and a potential bridge host between humans and NHP. This review highlights the lack of molecular data across all hosts—humans, NHP and dogs—with the latter highly underrepresented in the database. Despite the cosmopolitan nature of Strongyloides, there are still large gaps in our knowledge for certain species when considering transmission and pathogenicity. We suggest that a unified approach to Strongyloides detection be taken, with an optimized, repeatable molecular-based method to improve our understanding of this parasitic infection.
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