SCHIFF BASES AS POTENTIAL THERAPEUTIC AND ANTICANCER AGENTS

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Authors

BALLAYOVÁ Veronika KAUEROVÁ Tereza KOLLÁR Peter FARSA Oldřich

Year of publication 2023
Type Appeared in Conference without Proceedings
MU Faculty or unit

Faculty of Pharmacy

Citation
Description Basic thiosemicarbazone and semicarbazone derivatives of acetophenone with imine functional group belong to the group commonly called Schiff bases. Therapeutics and compounds belonging to this group are versatile pharmacophores with a significant capability of forming chelates with various metal ions. Such metal complexes play an important role in therapeutics due to their remarkable broad-spectrum of biological activities. Due to the above-mentioned complex formation, many Schiff bases appear as an important intermediate in a number of enzymatic reactions. One of the possible target enzyme is a neutral zinc-binding metalloenzyme aminopeptidase N (AP-N), also called membrane alanyl aminopeptidase. Potential inhibitors of this omnipresent enzyme may offer effective and broad-spectrum therapy. Through three-step synthesis it is possible to obtain three arene substitution isomers of basic thiosemicarbazone and semicarbazone derivatives of acetophenone.
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