Effects of various serotonin agonists, antagonists, and uptake inhibitors on the discriminative stimulus effects of methamphetamine in rats

Warning

This publication doesn't include Faculty of Sports Studies. It includes Faculty of Medicine. Official publication website can be found on muni.cz.

Authors	MUNZAR Patrik LAUFERT Michael D. KUTKAT Scott W. NOVÁKOVÁ Jana GOLDBERG Steven R.
Year of publication	1999
Type	Article in Periodical
Magazine / Source	The Journal of Pharmacology and Exper. Therapeutics
MU Faculty or unit	Faculty of Medicine
Citation
Web	https://jpet.aspetjournals.org/content/291/1/239.long
Field	Pharmacology and pharmaceutical chemistry
Keywords	Rats; methamphetamine; serotonin agonists; serotonin antagonists; serotonin uptake inhibitors; discriminative behaviour
Description	The present data suggest that the 5-HT system plays a modulatory role in the discriminative stimulus effects of methamphetamine. These effects appear to be mediated through 5-HT release and blockade of reuptake and subsequent activation of 5-HT(2A/2C) receptors, with limited involvement of other 5-HT receptor subtypes.
Related projects:	Plasticity of Regulatory Mechanisms of the Central Nervous Systems