FASTER THROMBOLYSIS IN VIVO

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Authors

BRHELOVÁ Eliška OPATŘILOVÁ Radka SCHEER Peter HLOŽKOVÁ Jana THALEROVÁ Sandra AKSU Ahmet Davut MIKULÍK Robert

Year of publication 2023
Type Conference abstract
MU Faculty or unit

Faculty of Pharmacy

Citation
Description This innovative experimental work focuses on the development of targeted thrombolytics combinations for the diagnosis and therapy of cerebral infarction, their preparation and testing in a rat animal model. The effect of the addition of plasminogen to the standard recombinant alteplase in the treatment of cerebral infarction was tested. A rat model of systemic embolism was used for this purpose. The design of the model is set to simulate as much as possible the course of thrombolysis in the human organism and the implementation of preclinical research into clinical practice is realistic.
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