RimM and RsfS ribosomal factors regulate the translation in bacteria

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Authors	HASSAN Ahmed Adel I. H. NAKANO Yuko BLAHA Gregor HOU Ya-Ming DEMO Gabriel
Year of publication	2023
Type	Conference abstract
MU Faculty or unit	Central European Institute of Technology
Citation
Description	It is crucial for bacteria to save energy when stressed or the access to nutrients is limited. Since synthesis of proteins is an important energy draining source, bacteria rely on slowing down the protein synthesis in harsh conditions. The ribosomal silencing factor (RsfS) has a significant role in stalling the protein synthesis by binding the 50S ribosomal subunit and inhibiting the assembly of 70S ribosome. Meanwhile, the ribosomal maturation factor RimM is vital for the maturation of the 30S small ribosomal subunit. Moreover, during stress RimM is highly enriched in the hibernating 100S dimerized ribosome to stall the protein synthesis and preserve energy. In this work, we use a combination of biochemical studies and cryo-electron microscopy to elucidate the close relationship between RimM and RsfS, and their regulation capabilities on translation.
Related projects:	Crosstalk between transcription and translation