Nanodiamonds as artificial proteins for regulation of a cell signalling system

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Authors

CÍGLER Petr BÁLEK Lukáš HAVLÍK Jan KREJČÍ Pavel TRANTÍREK Lukáš TRANTÍRKOVÁ Silvie

Year of publication 2023
Type Patent
MU Faculty or unit

Central European Institute of Technology

Publisher European Patent Office
State Germany
Patent's number EP3645018B1
Web Odkaz na databázi Evropského patentového úřadu
Description Here, we show that nanosized diamond crystals (nanodiamonds, NDs) without any synthetically installed (bio)organic interface enable the specific and efficient targeting of the family of extracellular signalling molecules known as fibroblast growth factors (FGFs). We found that at certain conditions the ND strongly associate with multiple FGF ligands present at sub-nanomolar concentrations and effectively neutralize the effects of FGF signalling in cells without interfering with other growth factor systems and serum proteins unrelated to FGFs.
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