The effect of intrapartum antibiotics prophylaxis on neonatal gut and oral bacteriome

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Authors

PIVRNCOVÁ Eliška KOTÁSKOVÁ Iva BUREŠOVÁ Lucie ANDRÝSKOVÁ Lenka PILER Pavel JANKŮ Petr BOREK Ivo KLÁNOVÁ Jana VÍDEŇSKÁ Petra BUDINSKÁ Eva BOŘILOVÁ LINHARTOVÁ Petra

Year of publication 2023
Type Conference abstract
MU Faculty or unit

Faculty of Science

Citation
Description The administration of intrapartum antibiotics prophylaxis (IAP) is commonly used in cesarean section and for the prevention of early-onset Group-B-streptococci infection. Since IAP may influence the microbiome development in neonates, our pilot study aimed to characterize the gut and oral bacteriome changes between neonates grouped according to their exposure to antibiotics during the delivery and sampling time in the first week of their life. 16S rDNA sequencing revealed differences in bacterial abundance in transitional stool samples, but not in meconium samples. Moreover, IAP influenced the oral bacteriome of neonates within 48 hours after birth. However, the effect of IAP on oral bacteriome seems to be suppressed later in the first week of their life.
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