The effect of intrapartum antibiotics prophylaxis on neonatal gut and oral bacteriome

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Authors	PIVRNCOVÁ Eliška KOTÁSKOVÁ Iva BUREŠOVÁ Lucie ANDRÝSKOVÁ Lenka PILER Pavel JANKŮ Petr BOREK Ivo KLÁNOVÁ Jana VÍDEŇSKÁ Petra BUDINSKÁ Eva BOŘILOVÁ LINHARTOVÁ Petra
Year of publication	2023
Type	Conference abstract
MU Faculty or unit	Faculty of Science
Citation
Description	The administration of intrapartum antibiotics prophylaxis (IAP) is commonly used in cesarean section and for the prevention of early-onset Group-B-streptococci infection. Since IAP may influence the microbiome development in neonates, our pilot study aimed to characterize the gut and oral bacteriome changes between neonates grouped according to their exposure to antibiotics during the delivery and sampling time in the first week of their life. 16S rDNA sequencing revealed differences in bacterial abundance in transitional stool samples, but not in meconium samples. Moreover, IAP influenced the oral bacteriome of neonates within 48 hours after birth. However, the effect of IAP on oral bacteriome seems to be suppressed later in the first week of their life.
Related projects:	CETOCOEN Excellence CETOCOEN Excellence e-Infrastruktura CZ National Center for Medical Genomics RECETOX research infrastructure