Titanium Dioxide Nanoparticles Modulate Systemic Immune Response and Increase Levels of Reduced Glutathione in Mice after Seven-Week Inhalation

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Authors

MIROSLAVA Lehotska Mikusova BUSOVA Milena TULINSKA Jana MASANOVA Vlasta LISKOVA Aurelia UHNAKOVA Iveta DUSINSKA Maria KRIVOSIKOVA Zora ROLLEROVA Eva ALACOVA Radka WSOLOVA Ladislava HORVATHOVA Mira SZABOVA Michaela LUKAN Norbert VECERA Zbynek COUFALIK Pavel KRUMAL Kamil ALEXA Lukas THON Vojtěch PILER Pavel BUCHTOVÁ Marcela VRLÍKOVÁ Lucie MORAVEC Pavel GALANDA Dusan MIKUSKA Pavel

Year of publication 2023
Type Article in Periodical
Magazine / Source Nanomaterials
MU Faculty or unit

Faculty of Science

Citation
Web https://www.mdpi.com/2079-4991/13/4/767
Doi http://dx.doi.org/10.3390/nano13040767
Keywords titanium dioxide nanoparticles; nanoparticle inhalation; immunotoxicity; immune response; lymphocytes; cytokines; inflammation; phagocytic activity and respiratory burst; antioxidant defense
Attached files
Description Titanium dioxide nanoparticles (TiO2 NPs) are used in a wide range of applications. Although inhalation of NPs is one of the most important toxicologically relevant routes, experimental studies on potential harmful effects of TiO2 NPs using a whole-body inhalation chamber model are rare. In this study, the profile of lymphocyte markers, functional immunoassays, and antioxidant defense markers were analyzed to evaluate the potential adverse effects of seven-week inhalation exposure to two different concentrations of TiO2 NPs (0.00167 and 0.1308 mg TiO2/m(3)) in mice. A dose-dependent effect of TiO2 NPs on innate immunity was evident in the form of stimulated phagocytic activity of monocytes in low-dose mice and suppressed secretory function of monocytes (IL-18) in high-dose animals. The effect of TiO2 NPs on adaptive immunity, manifested in the spleen by a decrease in the percentage of T-cells, a reduction in T-helper cells, and a dose-dependent decrease in lymphocyte cytokine production, may indicate immunosuppression in exposed mice. The dose-dependent increase in GSH concentration and GSH/GSSG ratio in whole blood demonstrated stimulated antioxidant defense against oxidative stress induced by TiO2 NP exposure.
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