Prognostic value and multifaceted roles of tetraspanin CD9 in cancer

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Authors

ONDRUŠŠEK Róbert KVOKAČKOVÁ Barbora KRYŠTOFOVÁ Karolína BRYCHTOVÁ Světlana SOUČEK Karel BOUCHAL Jan

Year of publication 2023
Type Article in Periodical
Magazine / Source Frontiers in Oncology
MU Faculty or unit

Faculty of Science

Citation
Web https://www.frontiersin.org/articles/10.3389/fonc.2023.1140738/full
Doi http://dx.doi.org/10.3389/fonc.2023.1140738
Keywords CD9; cancer; immunohistochemistry; prognosis; exosomes
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Description CD9 is a crucial regulator of cell adhesion in the immune system and plays important physiological roles in hematopoiesis, blood coagulation or viral and bacterial infections. It is involved in the transendothelial migration of leukocytes which might also be hijacked by cancer cells during their invasion and metastasis. CD9 is found at the cell surface and the membrane of exosomes affecting cancer progression and therapy resistance. High expression of CD9 is mostly associated with good patients outcome, with a few exceptions. Discordant findings have been reported for breast, ovarian, melanoma, pancreatic and esophageal cancer, which might be related to using different antibodies or inherent cancer heterogeneity. According to in vitro and in vivo studies, tetraspanin CD9 is not clearly associated with either tumor suppression or promotion. Further mechanistic experiments will elucidate the role of CD9 in particular cancer types and specific conditions.
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