Single-cell RNA-sequencing enables tracking and characterization of rare CLL cells with the potential to cause refractoriness.

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Authors	KURUCOVÁ Terézia RÉBLOVÁ Kamila VALIŠOVÁ Martina PORC Jakub Paweł NAVRKALOVÁ Veronika PAVLOVÁ Šárka MALČÍKOVÁ Jitka PLEVOVÁ Karla TICHÝ Boris DOUBEK Michael KOTAŠKOVÁ Jana POSPÍŠILOVÁ Šárka
Year of publication	2023
Type	Conference abstract
MU Faculty or unit	Central European Institute of Technology
Citation
Attached files	Kurucova_et_al._EHA2023.pdf
Description	Chronic lymphocytic leukemia (CLL) is considered an incurable disease due to the limited ability of current treatment options to completely eradicate leukemic cells. The therapy selection pressure favors the preferential proliferation of rare resistant cells, leading to recurrent relapses. Early detection of these rare cells holds the potential to assist in selecting appropriate therapy. To explore the possibility to identify and characterize rare populations of CLL cells resistant to treatment and causing relapses, and trace the presence of such cells during the disease course by single-cell RNA sequencing (scRNA-seq).
Related projects:	Single cell analysis: a modern tool to study clonal evolution in high-risk patients with chronic lymphocytic leukemia National institute for cancer research Nové přístupy ve výzkumu, diagnostice a terapii hematologických malignit X