CEREBROVASKULÁRNÍ PREKLINICKÝ VÝZKUM U POTKANŮ – KDYŽ TRANSLACE NARÁŽÍ NA KLINICKOU REALITU BEZ OHLEDU NA KALCÉMII

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Title in English CEREBROVASCULAR PRECLINICAL RESEARCH IN RATS - WHEN TRANSLATION HITS CLINICAL REALITY REGARDLESS OF CALCEMIA
Authors

SCHEER Peter DOLEŽALOVÁ Jana HLOŽKOVÁ Jana DAVUT AKSU Ahmet NOVOBILSKÝ Adam KUZMÍNOVÁ Gabriela BRHELOVÁ Eliška MIKULÍK Robert

Year of publication 2022
Type Conference abstract
MU Faculty or unit

Faculty of Pharmacy

Citation
Attached files
Description The use of artificial clots with a barium sulfate-based contrast agent allows the radiological quantification of the clot decay rate and the construction of a lytic curve. The simplicity, repeatability and robustness of the model will allow comparison of the thrombolytic effect of new potential thrombolytics. Modification of the classical MCAO model allows an informed safety assessment of new thrombolytics, combinations or dosing regimens.
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