Farmakologické vlastnosti kolistinu
| Title in English | Pharmacological properties of colistin |
|---|---|
| Authors | |
| Year of publication | 2022 |
| Type | Article in Periodical |
| Magazine / Source | Klinicka Mikrobiologie a Infekcni Lekarstvi |
| MU Faculty or unit | |
| Citation | |
| Web | https://www.trios.cz/wp-content/uploads/sites/149/2022/12/kmil-2-22.pdf |
| Keywords | colistin; pharmacodynamics; pharmacokinetics; nephrotoxicity; adverse effects; TDM |
| Description | Colistin is a narrow-spectrum lipopeptide antimicrobial agent used in the therapy of nosocomial infections caused by multi-resistant bacteria, especially in critically ill patients and patients with cystic fibrosis. Colistin represents a concentration-time-dependent antibiotic with highly variable pharmacokinetics related to the heterogenicity of the target population and the necessity of bioactivation. Colistin is administered as an inactive prodrug colistin methanesulphonate. Nephrotoxicity and neurotoxicity are the most frequent adverse effects. |
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