In vivo and in vitro effects of salidroside on liver cytochrome P450

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Authors	KLÁSKOVÁ Eva JUŘICA Jan HAMMER Tomáš MÁCHALOVÁ Alena MLČŮCHOVÁ Natálie VYKLICKÁ Kateřina BRENEROVÁ Petra BOŘILOVÁ LINHARTOVÁ Petra ZENDULKA Ondřej
Year of publication	2022
Type	Conference abstract
MU Faculty or unit	Faculty of Medicine
Citation	KLÁSKOVÁ, Eva, Jan JUŘICA, Tomáš HAMMER, Alena MÁCHALOVÁ, Natálie MLČŮCHOVÁ, Kateřina VYKLICKÁ, Petra BRENEROVÁ, Petra BOŘILOVÁ LINHARTOVÁ and Ondřej ZENDULKA. In vivo and in vitro effects of salidroside on liver cytochrome P450. In 19th International Medical Postgraduate Conference, From Bench to Bedside in PhD Research Projects. 2022.
Description	Salidroside (SAL) is one of the main active compounds of Rhodiola rosea, a herb with antidepressant and anxiolytic potential proven by clinical studies. Cytochromes P450 (CYP) are enzymes responsible for the metabolism of 70-80 % of medicaments in clinical practice. Since R. rosea is the ingredient of various over-the-counter food supplements, we have focused on its potential for pharmacokinetic interactions with the most important CYP isoforms.
Related projects:	RECETOX RI The influence of promising herbal antidepressant salidroside on drug metabolizing enzymes Preklinický a klinický výzkum Farmakologického ústavu v oblasti farmakokinetiky, neurobiologie závislostí a personalizované farmakoterapie v onkologii