Nejčastější chromozomální přestavby u dětí s akutní myeloidní leukemií a možnosti jejich sledování na molekulární úrovni

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Title in English The most frequent chromosomal aberrations in children with acute myeloid leukemia follow-up at the molecular level
Authors

MICHÁLEK Jaroslav ŠMARDA Jan ŠEVČÍKOVÁ Sabina HRSTKOVÁ Hana

Year of publication 1999
Type Article in Periodical
Magazine / Source Klinická onkologie
MU Faculty or unit

Faculty of Science

Citation
Field Genetics and molecular biology
Keywords acute myeloid leukemia in children; chromosomal aberration; PCR
Description Eighty percent of children suffering from AML show clonal chromosomal aberrations. The most frequent types t(8;21), t(15;17), inv(16) and 11q23 comprise 40-45% of all AML cases in children. Using molecular techniques long-term monitoring of residual disease has become possible, although the mass of leukemic cells has dropeed far below the dection level of morphologic and cytogenetic examination.
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