Nejčastější chromozomální přestavby u dětí s akutní myeloidní leukemií a možnosti jejich sledování na molekulární úrovni
| Title in English | The most frequent chromosomal aberrations in children with acute myeloid leukemia follow-up at the molecular level |
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| Authors | |
| Year of publication | 1999 |
| Type | Article in Periodical |
| Magazine / Source | Klinická onkologie |
| MU Faculty or unit | |
| Citation | |
| Field | Genetics and molecular biology |
| Keywords | acute myeloid leukemia in children; chromosomal aberration; PCR |
| Description | Eighty percent of children suffering from AML show clonal chromosomal aberrations. The most frequent types t(8;21), t(15;17), inv(16) and 11q23 comprise 40-45% of all AML cases in children. Using molecular techniques long-term monitoring of residual disease has become possible, although the mass of leukemic cells has dropeed far below the dection level of morphologic and cytogenetic examination. |
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