The effect of potential carcinogen harman on selected cytochrome P450 enzymes in rats

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Authors	KLÁSKOVÁ Eva STRAKOŠOVÁ Markéta JUŘICA Jan ZENDULKA Ondřej
Year of publication	2022
Type	Conference abstract
MU Faculty or unit	Faculty of Medicine
Citation
Description	Harman is a heterocyclic aromatic amine discovered in coffee, cigarette smoke, roasted meat, or fish. However, carcinogenic properties of harmane were proved - partly explained by its interaction via the AhR receptor and induction of CYP1A1. Cytochrome P450 (CYP) enzymes are responsible for the metabolism of 75 % of drugs used in clinical practice. Our study aimed to determine the effects of harman on the most important CYP variants in a preclinical experiment.
Related projects:	Preklinický a klinický výzkum Farmakologického ústavu v oblasti farmakokinetiky, neurobiologie závislostí a personalizované farmakoterapie v onkologii