Morbidity and psychomotor development of offspring of women with gestational diabetes: a 5-year follow-up

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Authors

BARTÁKOVÁ Vendula KREJČÍŘOVÁ Beáta CHALÁSOVÁ Katarína JANKŮ Petr KAŇKOVÁ Kateřina

Year of publication 2022
Type Article in Periodical
Magazine / Source BMC PEDIATRICS
MU Faculty or unit

Faculty of Medicine

Citation
Web https://bmcpediatr.biomedcentral.com/articles/10.1186/s12887-022-03543-4
Doi http://dx.doi.org/10.1186/s12887-022-03543-4
Keywords Gestational diabetes mellitus; Obesity; Offspring; Pregnancy; Prospective study
Description Background Gestational diabetes mellitus (GDM) represents a risk factor for both mother and her offspring in a short-term (perinatal morbidity) and long-term horizon (postpartum diabetes or foetal programming). Several studies focused at peri/postnatal outcomes of GDM mother´s offspring, however relatively few (and none in Czech population) were designed as prospective. The aim of the study was to ascertain eventual anthropometric and developmental abnormalities and/or morbidity in offspring of GDM mothers compare to controls in a 5-year follow-up using a parent-reported parameters related to psychomotor development and common paediatric morbidities including a sub-study of offspring of GDM mothers experiencing adverse perinatal outcomes. Methods A 5 year follow up study of offspring of GDM mothers (n?=?26) vs those with a normal pregnancy (n?=?63). An electronic questionnaire was used to obtain the parameters (such as growth, psychomotor development, vaccination, morbidity history etc.) available to parents from the parent-held infant health record. Data on pregnancy and delivery were available from the previous study. Results Offspring of GDM mothers had delayed psychomotor development in early childhood, but in 5 years of age they seemed to gradually achieve results of a control group. Children with macrosomia had a higher percentile of weight-for-height and were significantly more frequently ill than those with a normal birth weight. Offspring of obese mothers had worse verbal language skills in early childhood and a higher percentile of weight-for-height. Conclusion Maternal gestational diabetes and obesity can be considered an important determinant of postnatal offspring development and health status, which further advocates for broader implementation of preventive strategies.
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