Current State of CAR T-Cell Therapy in Chronic Lymphocytic Leukemia

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Authors	MANČÍKOVÁ Veronika ŠMÍDA Michal
Year of publication	2021
Type	Article in Periodical
Magazine / Source	International Journal of Molecular Sciences
MU Faculty or unit	Central European Institute of Technology
Citation
Web	https://www.mdpi.com/1422-0067/22/11/5536
Doi	http://dx.doi.org/10.3390/ijms22115536
Keywords	chimeric antigen receptor; immunotherapy; chronic lymphocytic leukemia; CD19
Description	Chimeric antigen receptor (CAR) T-cell therapy has already achieved remarkable remissions in some difficult-to-treat patients with B-cell malignancies. Although the clinical experience in chronic lymphocytic leukemia (CLL) patients is limited, the proportion of remissions reached in this disease is clearly the lowest from the spectrum of B-cell tumors. In this review, we discuss the antigenic targets exploited in CLL CAR-T therapy, the determinants of favorable responses, as well as the mechanisms of treatment failure specific to this disease.
Related projects:	CEITEC 2020