Antioxidants in patients living with HIV on antiretrovirals

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Authors	HAVLÍČKOVÁ Kateřina SNOPKOVÁ Svatava POHANKA Miroslav SVAČINKA Radek HUSA Petr ZLÁMAL Filip FABIANOVÁ Lenka HUSA Petr
Year of publication	2021
Type	Article in Periodical
Magazine / Source	MILITARY MEDICAL SCIENCE LETTERS - VOJENSKÉ ZDRAVOTNICKÉ LISTY
MU Faculty or unit	Faculty of Medicine
Citation
Web	https://www.mmsl.cz/magno/mms/2021/mn2.php
Doi	http://dx.doi.org/10.31482/mmsl.2021.005
Keywords	Antiretroviral therapy; glutathione; HIV; oxidative stress
Attached files	2_MMSL_2021_2_WWW.pdf
Description	Introduction Oxidative stress is considered predictors of diseases associated with aging (cardiovascular disease, neurodegenerative disease, malignancies, and others) in HIV-negative general population. Antioxidants were investigated in people living with HIV on antiretroviral treatment to determine whether they had an immunosenescent phenotype that might predispose to the development of premature age-related diseases. Clinical studies in this population are controversial. Methods The study was conducted among 213 subjects with HIV, including 172 subjects on antiretrovirals and 41 subjects before the initiation of treatment. The control group consisted of healthy HIV-negative adults. We compared the reduced glutathione and ferric reducing antioxidant power levels in HIV untreated and treated patients and controls. Significant differences were determined by appropriate statistical tests (t-test, Mann–Whitney U test, Kolmogorov–Smirnov test, ANOVA, Kruskal–Wallis test). Relationships between continuous variables were quantified using Spearman’s rank correlation coefficient. Results Glutathione levels were significantly lower in the treated group compared with the untreated group and controls (P ? 0.001). Differences in total antioxidant levels between groups were not found. Conclusions Significant decrease of antioxidants was found independent of the virologic status of HIV patients on antiretroviral treatment. Persistence of these abnormal parameters may contribute and predispose to the premature development of diseases associated with aging.