The 9aaTAD Activation Domains in the Yamanaka Transcription Factors Oct4, Sox2, Myc, and Klf4

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Authors

PISKÁČEK Martin OTAŠEVIČ Tomáš REPKO Martin KNIGHT Andrea

Year of publication 2021
Type Article in Periodical
Magazine / Source Stem Cell Reviews and Reports
MU Faculty or unit

Faculty of Medicine

Citation
Web https://link.springer.com/article/10.1007/s12015-021-10225-8
Doi http://dx.doi.org/10.1007/s12015-021-10225-8
Keywords Stem cell; iPSCs; SoxE; Sox9; KIX; CBP; MED15
Description Somatic cells can be reprogrammed by the Yamanaka factors Oct4, Sox2, Myc and Klf4 into pluripotent stem cells. Previously, we have identified the activation domain 9aaTAD in the related SP, KLF and SOX activators. In this study, we searched for the 9aaTAD domains in Yamanaka factors, which are activators of transcription.
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