Type 2 diabetes genetic risk score and morbidity and mortality associated with diabetic kidney disease

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Authors	GALUŠKA David JANÁKOVÁ Michaela BEDNÁRIKOVÁ Beáta CHALÁSOVÁ Katarína PÁCAL Lukáš KAŇKOVÁ Kateřina
Year of publication	2019
Type	Conference abstract
MU Faculty or unit	Faculty of Medicine
Citation
Description	Diabetic kidney disease (DKD) is one of the most serious complications of type 2 diabetes mellitus (T2DM). Individual predisposition to development and progression of DKD has well established genetic component however it is still insufficiently explored. Genetic predisposition to T2DM is comprehensively described and genetic risk score (GRS) composed of 65 SNPs that is associated with 3-times higher risk of T2DM development has been established. In our study we tested the hypothesis that reduced GRS (comprised of 21 SNP with highest OR) might represent a risk factor for DKD progression and cardiovascular morbidity and mortality in T2DM patients in the Czech population.
Related projects:	Genetické skóre v predikci rizika diabetu a jeho komplikací