The rDNA Loci-Intersections of Replication, Transcription, and Repair Pathways
| Authors | |
|---|---|
| Year of publication | 2021 |
| Type | Article in Periodical |
| Magazine / Source | International Journal of Molecular Sciences |
| MU Faculty or unit | |
| Citation | |
| Web | https://doi.org/10.3390/ijms22031302 |
| Doi | http://dx.doi.org/10.3390/ijms22031302 |
| Keywords | rDNA organization; genome stability; rRNA genes; ribosome; CAF-1; RAD51; RTEL1 |
| Attached files | |
| Description | Genes encoding ribosomal RNA (rDNA) are essential for cell survival and are particularly sensitive to factors leading to genomic instability. Their repetitive character makes them prone to inappropriate recombinational events arising from collision of transcriptional and replication machineries, resulting in unstable rDNA copy numbers. In this review, we summarize current knowledge on the structure and organization of rDNA, its role in sensing changes in the genome, and its linkage to aging. We also review recent findings on the main factors involved in chromatin assembly and DNA repair in the maintenance of rDNA stability in the model plants Arabidopsis thaliana and the moss Physcomitrella patens, providing a view across the plant evolutionary tree. |
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