TGF-beta regulates Sca-1 expression and plasticity of pre-neoplastic mammary epithelial stem cells

• Authors: REMŠÍK Ján; PÍCKOVÁ Markéta; VACEK Ondřej; FEDR Radek; BINO Lucia; HAMPL Aleš; SOUČEK Karel
• Year of publication: 2020
• Type: Article in Periodical
• Magazine / Source: Scientific reports
• MU Faculty or unit: Faculty of Science
• Web: https://doi.org/10.1038/s41598-020-67827-4
• Doi: http://dx.doi.org/10.1038/s41598-020-67827-4
• Keywords: Breast cancer; Cancer stem cells
• Description: The epithelial-mesenchymal plasticity, in tight association with stemness, contributes to the mammary gland homeostasis, evolution of early neoplastic lesions and cancer dissemination. Focused on cell surfaceome, we used mouse models of pre-neoplastic mammary epithelial and cancer stem cells to reveal the connection between cell surface markers and distinct cell phenotypes. We mechanistically dissected the TGF-beta family-driven regulation of Sca-1, one of the most commonly used adult stem cell markers. We further provided evidence that TGF-beta disrupts the lineage commitment and promotes the accumulation of tumor-initiating cells in pre-neoplastic cells.

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