Interacting effects of the MAM model of schizophrenia and antipsychotic treatment: Untargeted proteomics approach in adipose tissue

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Authors	KUČERA Jan HORSKÁ Kateřina HRUŠKA Pavel KURUCZOVÁ Daniela MICALE Vincenzo RUDÁ Jana DOBROVOLNÁ Julie
Year of publication	2021
Type	Article in Periodical
Magazine / Source	Progress in Neuro-Psychopharmacology & Biological Psychiatry
MU Faculty or unit	Faculty of Pharmacy
Citation
Web	https://www.sciencedirect.com/science/article/pii/S0278584620304814?via%3Dihub
Doi	http://dx.doi.org/10.1016/j.pnpbp.2020.110165
Keywords	Antipsychotics; Adipose tissue; Schizophrenia; Animal model; Proteomics; Methylazoxymethanol
Description	Highlights Proteomics show deregulated mTOR in adipose tissue of schizophrenia-like rat model. Antipsychotics alter adipose proteome in schizophrenia-like rats but not in controls. Different antipsychotics have a distinct impact on the adipose tissue proteome. Antipsychotics modify metabolic and energetic pathways in adipose tissue.
Related projects:	Preklinický a klinický výzkum studentů v oblasti farmakokinetiky, neuropsychofarmakologie a personalizované farmakoterapie v onkologii Od molekulární, buněčné a tkáňové k systémové patofyziologii vybraných komplexních nemocí