Role of Sodium/Calcium Exchangers in Tumors

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Authors	CHOVANCOVA Barbora LISKOVA Veronika BABULA Petr KRIŽANOVÁ Olga
Year of publication	2020
Type	Article in Periodical
Magazine / Source	Biomolecules
MU Faculty or unit	Faculty of Medicine
Citation
Web	https://www.mdpi.com/2218-273X/10/9/1257
Doi	http://dx.doi.org/10.3390/biom10091257
Keywords	sodium-calcium exchanger; cancer cells; calcium; apoptosis
Description	The sodium/calcium exchanger (NCX) is a unique calcium transport system, generally transporting calcium ions out of the cell in exchange for sodium ions. Nevertheless, under special conditions this transporter can also work in a reverse mode, in which direction of the ion transport is inverted-calcium ions are transported inside the cell and sodium ions are transported out of the cell. To date, three isoforms of the NCX have been identified and characterized in humans. Majority of information about the NCX function comes from isoform 1 (NCX1). Although knowledge about NCX function has evolved rapidly in recent years, little is known about these transport systems in cancer cells. This review aims to summarize current knowledge about NCX functions in individual types of cancer cells.