NANO-GOLD APPLICATIONS IN MALDI TOF MS OF PEPTIDES
| Authors | |
|---|---|
| Year of publication | 2011 |
| Type | Article in Proceedings |
| Conference | BIOLOGICALLY ACTIVE PEPTIDES |
| MU Faculty or unit | |
| Citation | |
| Web | https://doi.org/10.1135/css201113120 |
| Doi | http://dx.doi.org/10.1135/css201113120 |
| Keywords | Nano-gold; Peptides; MALDI TOF MS; Microextraction |
| Description | Gold particles (dimensions are ranging from 1 to several hundreds of nm) called nano-gold (NG) interact with DNA, nucleotides, peptides, proteins, etc. They are applied for tissue coloring, cellular detection, drug-delivery, detection and treatment of cancer, etc. In this work the use of NG in mass spectrometry of peptides was studied. It was found that (i) NG can be used as a matrix for peptide ionization, (ii) Au-n(+) clusters formed can be in the same time used as internal calibrants, and (iii) NG can also be used for peptide micropxtraction and consequent MALDI analysis. |
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