Neonatal CB1 receptor blockade differentially affects behavioural responses in normal and prenatally MAM exposed rats

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Authors

ŠTARK Tibor IANNOTTI F. A. PISCITELLI F. RUDÁ Jana DRAGO F. SULCOVA A. DI MARZO V. MICALE Vincenzo

Year of publication 2019
Type Conference abstract
MU Faculty or unit

Faculty of Medicine

Citation
Description c phenotype at adulthood. Delayed acquirement of early motor development milestones and significant deficits in motor function in individuals who subsequently develop schizophrenia have been a principal piece of evidence supporting this hypothesis. Animal models based on neurodevelopmental premise yield an advantage to assess alterations which could precede and/or contribute to the onset of the typical adult phenotype. Numerous studies support a dysregulation of the endocannabinoid system (ECS), both in terms of CB1 or CB2 receptors and endocannabinoid ligands anandamide or 2-arachidonoylglycerol (2-AG) seems to be involved in the pathophysiology of the psychosis as well.
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