MicroRNA analysis in multiple myeloma and extramedullary disease

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Authors	GREGOROVÁ Jana RADOVÁ Lenka GABŁO Natalia Anna ALMASI M. STORK M. SLABÝ Ondřej POUR L. MINARIK J. ŠEVČÍKOVÁ Sabina
Year of publication	2019
Type	Conference abstract
MU Faculty or unit	Faculty of Medicine
Citation
Description	MicroRNAs (miRNAs) are short non-coding RNA molecules that are involved in many physiological and pathological processes. Multiple myeloma (MM) is the second most common hematological malignancy of plasma cells (PCs). Survival of patients is negatively affected by extramedullary disease (EM). EM occurs when PCs migrate out of the bone marrow (BM) and lose the dependence to its microenvironment. The mechanism by which the EM occurs is not yet elucidated. The importance of miRNA in the pathogenesis of MM has been demonstrated by several studies. We assume that they are involved in the development of EM. Aims: The aim of this work was to analyze different expression of miRNA in BM PCs of EM vs MM patients.
Related projects:	Analýza mikroprostředí kostní dřeně u extramedulárního relapsu mnohočetného myelomu