Účinná imunoterapie glioblastomu u adolescenta se syndromem konstitučního deficitu v mismatch repair opravném systému

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Title in English Effective Immunotherapy of Glioblastoma in an Adolescent with Constitutional Mismatch Repair-Deficiency Syndrome
Authors

PAVELKA Zdeněk ZITTERBART Karel NOSKOVÁ Hana BAJČIOVÁ Viera SLABÝ Ondřej ŠTĚRBA Jaroslav

Year of publication 2019
Type Article in Periodical
Magazine / Source Klinická onkologie
MU Faculty or unit

Faculty of Medicine

Citation
Web http://dx.doi.org/10.14735/amko201970
Doi http://dx.doi.org/10.14735/amko201970
Keywords hereditary cancer predisposition syndromes; glioblastoma; whole exome sequencing; immunotherapy; vaccines; checkpoint inhibitors
Description Individuals with constitutional mismatch repair-deficiency syndrome (CMMR-D) are characterised by early occurrence of colon cancer, haematological malignancies, and brain tumors (malignant gliomas, high-grade gliomas) in childhood, adolescence, and early adulthood. High mutational tumor burden is typical of glioblastoma in CMMR-D patients and could be a reason why this type of glioblastoma responds well to immunotherapies, including those that employ checkpoint inhibitors.
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