Peripubertal treatment with cannabidiol reverses behavioral alterations in Delta 9-THC animal model of schizophrenia

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Authors	ŠTARK Tibor GIURDANELLA Giovanni PEKAŘÍK Vladimír KUCHAR Martin BABINSKÁ Zuzana RUDÁ Jana SALOMONE Salvatore MECHOULAM Raphael DRAGO Filippo ŠULCOVÁ Alexandra MICALE Vincenzo
Year of publication	2019
Type	Conference abstract
MU Faculty or unit	Faculty of Medicine
Citation
Description	Several studies suggest that disturbances in the neurodevelopment could lead to schizophrenia (SCZ), a psychiatric disorder with severe symptoms in cognitive and social domains. While a variety of studies emphasize the role of the endocannabinoid system (ECS) in the neurodevelopmental dysregulation during perinatal and adolescent periods, mostly arising fromwell-known long-lasting negative effects of delta-9-tetrahydrocannabinol very little attention is dedicated to the positive potential of the ECS modulation in these sensitive periods as a preventive intervention. Given that preventive antipsychotic treatment seems to reduce the risk of transition to psychosis in vulnerable individuals, we hypothesized early modulation of ECS could be a potential novel therapeutic strategy.
Related projects:	Behaviorální psychofarmakologie a farmakokinetika v preklinickém výzkumu léčiv