Tyrosine kinase inhibitors in the first-line treatment for metastatic nonclear cell renal carcinoma: A retrospective analysis of a national database

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Authors

POPRACH Alexandr RUMANOVÁ Kristína LAKOMÝ Radek CHLOUPKOVÁ Renata STANÍK Michal POKRIVČÁK Tomáš KISS Igor SLABÝ Ondřej STUDENTOVA Hana MELICHAR Bohuslav JURÁČEK Jaroslav FIALA Ondrej KOPECKY Jindrich KOPECKOVA Katerina ZEMANOVA Milada BÜCHLER Tomáš

Year of publication 2019
Type Article in Periodical
Magazine / Source UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
MU Faculty or unit

Faculty of Medicine

Citation
Web http://dx.doi.org/10.1016/j.urolonc.2018.12.017
Doi http://dx.doi.org/10.1016/j.urolonc.2018.12.017
Keywords Nonclear cell renal carcinoma; Targeted therapy; Sunitinib; Pazopanib
Description Background: Nonclear cell renal cell carcinoma (nccRCC) is a heterogeneous group of primary kidney tumors. The aim of the present retrospective study was to analyze outcomes of patients with nccRCC treated with tyrosine-kinase inhibitors (TKIs) based on a national registry. Methods: The registry contained evaluable data of 93 nccRCC patients treated with first-line TKIs, including 87 patients with papillary renal cell carcinoma (RCC) and 6 patients with chromophobe RCC. The control cohort consisted of 1,788 patients with clear-cell RCC treated with firstline TKIs. Multivariable Cox proportional hazard model was used to evaluate the effect of potential prognostic factors on the survival measures. Results: Median progression-free survival was 11.8 and 6.5 months in the clear cell renal cell carcinoma and nccRCC patients, respectively (P = 0.018), and median overall survival was 33.2 and 22.0 months, respectively (P = 0.007). In the multivariate analysis, independent factors associated with inferior progression-free survival included high tumor grade, worse Memorial Sloan Kettering Cancer Center risk group, absence of nephrectomy, and sunitinib (as opposed to pazopanib) as first-line targeted therapy. Independent predictors of inferior overall survival included nonclear cell histology, tumor grade, worse Memorial Sloan Kettering Cancer Center risk group, absence of nephrectomy, older age, and sunitinib as first-line targeted therapy. Conclusions: The present retrospective, registry-based study confirms that patients with nccRCC treated with TKIs have worse clinical outcomes compared to clear cell renal cell carcinoma patients with similar baseline characteristics. (C) 2018 Elsevier Inc. All rights reserved.
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