Long Non-Coding RNAs in Multiple Myeloma

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Authors

BÚTOVÁ Romana VYCHYTILOVÁ-FALTEJSKOVA Petra SOUČKOVÁ Adéla ŠEVČÍKOVÁ Sabina HÁJEK Roman

Year of publication 2019
Type Article in Periodical
Magazine / Source Non-coding RNA
MU Faculty or unit

Faculty of Medicine

Citation
Web http://dx.doi.org/10.3390/ncrna5010013
Doi http://dx.doi.org/10.3390/ncrna5010013
Keywords Biomarker; Long non-coding RNAs; Multiple myeloma
Description Multiple myeloma (MM) is the second most common hematooncological disease of malignant plasma cells in the bone marrow. While new treatment brought unprecedented increase of survival of patients, MM pathogenesis is yet to be clarified. Increasing evidence of expression of long non-coding RNA molecules (lncRNA) linked to development and progression of many tumors suggested their important role in tumorigenesis. To date, over 15,000 lncRNA molecules characterized by diversity of function and specificity of cell distribution were identified in the human genome. Due to their involvement in proliferation, apoptosis, metabolism, and differentiation, they have a key role in the biological processes and pathogenesis of many diseases, including MM. This review summarizes current knowledge of non-coding RNAs (ncRNA), especially lncRNAs, and their role in MM pathogenesis. Undeniable involvement of lncRNAs in MM development suggests their potential as biomarkers.
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