Symmetry Breaking for GATA-1/PU.1 Model

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Authors

PŘIBYLOVÁ Lenka LOSOVÁ Barbora

Year of publication 2019
Type Article in Proceedings
Conference Computational Methods in Systems Biology. CMSB 2019. Lecture Notes in Computer Science
MU Faculty or unit

Faculty of Science

Citation
Web https://link.springer.com/chapter/10.1007/978-3-030-31304-3_27
Doi http://dx.doi.org/10.1007/978-3-030-31304-3_27
Keywords Bistability Symmetry breaking; Pitchfork bifurcation; GATA-1/PU.1 model; Biochemical switch
Description This paper explains a substantial feature of symmetry breaking of dynamical systems that include bistability from the mathematical point of view to highlight important consequences of this phenomenon to biochemical and system biology studies since symmetry breaking as a bifurcation itself can serve as a source of branching. We take hematopoietic stem cells modeling as a particular case.
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