Symmetry Breaking for GATA-1/PU.1 Model

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Authors	PŘIBYLOVÁ Lenka LOSOVÁ Barbora
Year of publication	2019
Type	Article in Proceedings
Conference	Computational Methods in Systems Biology. CMSB 2019. Lecture Notes in Computer Science
MU Faculty or unit	Faculty of Science
Citation
Web	https://link.springer.com/chapter/10.1007/978-3-030-31304-3_27
Doi	http://dx.doi.org/10.1007/978-3-030-31304-3_27
Keywords	Bistability Symmetry breaking; Pitchfork bifurcation; GATA-1/PU.1 model; Biochemical switch
Description	This paper explains a substantial feature of symmetry breaking of dynamical systems that include bistability from the mathematical point of view to highlight important consequences of this phenomenon to biochemical and system biology studies since symmetry breaking as a bifurcation itself can serve as a source of branching. We take hematopoietic stem cells modeling as a particular case.
Related projects:	Matematické statistické modelování 3