Trop-2 plasticity is controlled by epithelial-to-mesenchymal transition
| Authors | |
|---|---|
| Year of publication | 2018 |
| Type | Article in Periodical |
| Magazine / Source | Carcinogenesis |
| MU Faculty or unit | |
| Citation | |
| Web | https://academic.oup.com/carcin/article-abstract/39/11/1411/5054274?redirectedFrom=fulltext |
| Doi | http://dx.doi.org/10.1093/carcin/bgy095 |
| Keywords | cancer plasticity; epithelial-to-mesenchymal transition; intratumoral heterogeneity; Trop-2 |
| Description | The cell surface glycoprotein Trop-2 is commonly overexpressed in carcinomas and represents an exceptional antigen for targeted therapy. Here, we provide evidence that surface Trop-2 expression is functionally connected with an epithelial phenotype in breast and prostate cell lines and in patient tumor samples. We further show that Trop-2 expression is suppressed epigenetically or through the action of epithelial-to-mesenchymal transition transcription factors and that deregulation of Trop-2 expression is linked with cancer progression and poor patient prognosis. Moreover, our data suggest that the cancer plasticity-driven intratumoral heterogeneity in Trop-2 expression may significantly contribute to response and resistance to therapies targeting Trop-2-expressing cells. |
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