Trop-2 plasticity is controlled by epithelial-to-mesenchymal transition

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Authors

REMŠÍK Ján BINÓ Lucia KAHOUNOVÁ zuzana KHARAISHVILI Gvantsa ŠIMEČKOVÁ Šárka FEDR Radek KUČÍRKOVÁ Tereza LENÁRT Sára MURESAN Ximena Maria SLABÁKOVÁ Eva KNOPFOVÁ Lucia BOUCHAL Jan KRÁL Milan BENEŠ Petr SOUČEK Karel

Year of publication 2018
Type Article in Periodical
Magazine / Source Carcinogenesis
MU Faculty or unit

Faculty of Science

Citation
Web https://academic.oup.com/carcin/article-abstract/39/11/1411/5054274?redirectedFrom=fulltext
Doi http://dx.doi.org/10.1093/carcin/bgy095
Keywords cancer plasticity; epithelial-to-mesenchymal transition; intratumoral heterogeneity; Trop-2
Description The cell surface glycoprotein Trop-2 is commonly overexpressed in carcinomas and represents an exceptional antigen for targeted therapy. Here, we provide evidence that surface Trop-2 expression is functionally connected with an epithelial phenotype in breast and prostate cell lines and in patient tumor samples. We further show that Trop-2 expression is suppressed epigenetically or through the action of epithelial-to-mesenchymal transition transcription factors and that deregulation of Trop-2 expression is linked with cancer progression and poor patient prognosis. Moreover, our data suggest that the cancer plasticity-driven intratumoral heterogeneity in Trop-2 expression may significantly contribute to response and resistance to therapies targeting Trop-2-expressing cells.
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