Dynamics of allergy development during the first 5 years of life

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Authors

VRBOVÁ Markéta DOROCIAKOVÁ Petra VYŠKOVSKÝ Roman MURINOVA PALKOVICOVA Lubica ČIŽNÁR Peter RAUSOVA Katarina MCNABB Scott J. N. REICHRTOVA Eva BUDINSKÁ Eva THON Vojtěch

Year of publication 2018
Type Article in Periodical
Magazine / Source European journal of pediatrics
MU Faculty or unit

Faculty of Science

Citation
Web https://link.springer.com/article/10.1007%2Fs00431-018-3188-9
Doi http://dx.doi.org/10.1007/s00431-018-3188-9
Keywords Allergy; Asthma; Atopic dermatitis; Atopic march; Questionnaire; Rhino conjunctivitis
Description Allergic diseases have increased in developed countries during the past decades. A cohort of Slovak children was followed from birth to track allergic symptoms dynamics in early childhood. Information on allergic symptoms (atopic dermatitis = AD, rhino conjunctivitis = RC, wheezing = Wh, urticaria = Ur) and food allergies among children was based on clinical evaluation of children by allergists at three developmental stages (infant, toddler, preschool). Out of 320 cases of allergies, 64 infants, 145 toddlers, and 195 preschool children suffered from AD, RC, Wh, Ur, or their combinations (i.e., significant increase with age, p < 0.001). AD first appeared in infants, Wh and/or RC rose mainly in toddlers, and Ur among preschool children. AD in infants or toddlers disappeared in the subsequent developmental stage in approximately one third of all cases. Single AD persistence without remission or extension was not common and accounted only for 6.9% of AD infants' allergic manifestations. In addition to single-symptom allergic diseases, this study also identified several combinations of atopic symptoms. Conclusions: The proportion of multi-symptom allergies increased while single-symptom forms decreased. The observed temporal trends of allergic symptoms correspond to the atopic march.
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