The role of 3 ' end uridylation in RNA metabolism and cellular physiology

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Authors

ZIGÁČKOVÁ Dagmar VAŇÁČOVÁ Štěpánka

Year of publication 2018
Type Article in Periodical
Magazine / Source PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
MU Faculty or unit

Central European Institute of Technology

Citation
Web https://royalsocietypublishing.org/doi/10.1098/rstb.2018.0171
Doi http://dx.doi.org/10.1098/rstb.2018.0171
Keywords RNA uridylation; tutase; RNA modification; RNA surveillance; RNA processing; RNA degradation
Description Most eukaryotic RNAs are posttranscriptionally modified. The majority of modifications promote RNA maturation, others may regulate function and stability. The 3' terminal non-templated oligouridylation is a widespread modification affecting many cellular RNAs at some stage of their life cycle. It has diverse roles in RNA metabolism. The most prevalent is the regulation of stability and quality control. On the cellular and organismal level, it plays a critical role in a number of pathways, such as cell cycle regulation, cell death, development or viral infection. Defects in uridylation have been linked to several diseases. This review summarizes the current knowledge about the role of the 3' terminal oligo(U)-tailing in biology of various RNAs in eukaryotes and describes key factors involved in these pathways. This article is part of the theme issue '5' and 3' modifications controlling RNA degradation'.
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