Advantages in Prognosis of Adult Patients with Ewing Sarcoma: 11-years Experiences and Current Treatment Management

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Authors

ADÁMKOVÁ KRÁKOROVÁ Dagmar KUBACKOVA Katerina DUŠEK Ladislav TOMÁŠ Tomáš JANÍČEK Pavel TUČEK Štěpán PRAUSOVA Jana KISS Igor ZAMBO Iva

Year of publication 2018
Type Article in Periodical
Magazine / Source PATHOLOGY & ONCOLOGY RESEARCH
MU Faculty or unit

Faculty of Medicine

Citation
Doi http://dx.doi.org/10.1007/s12253-017-0291-6
Keywords Ewing sarcoma; Adults; Multimodal treatment; Risk factors; Prognosis
Description Ewing sarcoma (ES) is an exceptionally rare tumor in adults. Data regarding outcomes of adult patients with ES and experiences with age-adapted therapeutic strategies are very limited. The aim of this study was to evaluate prognostic factors and clinical outcome in a cohort of adult patients treated according to pediatric protocols in the Czech Republic. The records of 58 adult ES patients diagnosed between 2002 and 2013 were reviewed and factors relevant to prognosis and survival were analyzed. The median age of study cohort was 29 years (range, 18-59). The most frequent location was axial (36.2%), followed by involvement of extraskeletal tissues (34.5%) and bones of the extremities (29.3%). Twenty-eight (48.3%) patients had metastatic disease. In cases with localized ES, the 5-year overall survival (OS) was 76.5%. Using the log-rank test, the presence of metastasis at diagnosis, local treatment without surgery and a failure to achieve complete remission were associated with significantly shorter survival. In a multivariate Cox proportional hazard analysis, the achievement of complete remission was an independent predictor of patients's survival time. Outcomes of adults with localized ES treated according to multimodal pediatric protocols are similar to children. The achievement of complete remission is an independent predictor of survival time in ES patients. Severe hematological toxicity is foreseeable and manageable. Prognosis of patients with metastases or progression remains dismal.

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