Both ketamine and NBQX attenuate alcohol drinking in male Wistar rats

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Authors

RUDÁ Jana BABINSKÁ Zuzana ĽUPTÁK Matej GETACHEW Bruk TIZABI Yousef

Year of publication 2018
Type Article in Periodical
Magazine / Source Neuroscience Letters
MU Faculty or unit

Faculty of Medicine

Citation
Web https://www.sciencedirect.com/science/article/pii/S030439401731025X
Doi http://dx.doi.org/10.1016/j.neulet.2017.12.055
Field Pharmacology and pharmaceutical chemistry
Keywords Alcoholism; Alcohol use disorder; Glutamatergic receptors; NMDA receptor; AMPA receptor; Kainate receptor
Description Highlights: Acute low dose ketamine reduced alcohol intake but not alcohol-related behavioural effects. Acute low dose NBQX reduced alcohol intake but not alcohol-related behavioural effects. NMDA or AMPA/kainate receptor antagonists may have treatment potential in alcohol use disorder. These results suggest that selective antagonism of the NMDA or AMPA/kainate receptors may be of therapeutic potential in AUD.
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