Both ketamine and NBQX attenuate alcohol drinking in male Wistar rats

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Authors	RUDÁ Jana BABINSKÁ Zuzana ĽUPTÁK Matej GETACHEW Bruk TIZABI Yousef
Year of publication	2018
Type	Article in Periodical
Magazine / Source	Neuroscience Letters
MU Faculty or unit	Faculty of Medicine
Citation
Web	https://www.sciencedirect.com/science/article/pii/S030439401731025X
Doi	http://dx.doi.org/10.1016/j.neulet.2017.12.055
Field	Pharmacology and pharmaceutical chemistry
Keywords	Alcoholism; Alcohol use disorder; Glutamatergic receptors; NMDA receptor; AMPA receptor; Kainate receptor
Description	Highlights: Acute low dose ketamine reduced alcohol intake but not alcohol-related behavioural effects. Acute low dose NBQX reduced alcohol intake but not alcohol-related behavioural effects. NMDA or AMPA/kainate receptor antagonists may have treatment potential in alcohol use disorder. These results suggest that selective antagonism of the NMDA or AMPA/kainate receptors may be of therapeutic potential in AUD.
Related projects:	Experimentální a translační farmakologický výzkum a vývoj Behaviorální psychofarmakologie a farmakokinetika v preklinickém výzkumu léčiv