Dvě odlišné linie plazmidů kódujících exfoliativní toxin B identifikované v českých kmenech Staphylococcus aureus
| Title in English | Two different lineages of exfoliative toxin B-encoding plasmids identified in Czech strains of Staphylococcus aureus |
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| Authors | |
| Year of publication | 2017 |
| Type | Article in Periodical |
| Magazine / Source | Zprávy Centra Epidemiologie a Mikrobiologie |
| MU Faculty or unit | |
| Citation | |
| web | https://www.researchgate.net/publication/322245136_Dve_odlisne_linie_plazmidu_kodujicich_exfoliativni_toxin_B_identifikovane_v_ceskych_kmenech_Staphylococcus_aureus |
| Field | Genetics and molecular biology |
| Keywords | Staphylococcus aureus; ST121; exfoliative toxin B-encoding plasmids |
| Description | Staphylococcus aureus is an important opportunistic pathogen and a common cause of bacterial nosocomial infections. Pathogenic properties of this bacterium are often encoded by mobile genetic elements, such as plasmids. Plasmids also carry the etb gene encoding exfoliative toxin B (ETB), which is the cause of a blistering disease (bullous impetigo) whose generalized and life-threatening form is known as staphylococcal scalded skin syndrome. Comparative sequence analysis was conducted to study five etb-positive plasmids, isolated from clinical S. aureus strains from Czech hospitals between 1999 and 2015. They were found to share a large part of the DNA sequence comprising typical virulence genes. However, they also contain variable fragments, which help us to differentiate between them. Although ETB plasmids were previously assumed to be relatively uniform, a new type showing minimal sequence similarity to other ETB plasmids was isolated and described. Moreover, it carries genes for horizontal transfer by conjugation as well as new variants of genes for virulence factors, including etb, and as such it represents a completely new lineage of exfoliative toxin B-encoding plasmids. |
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