Mutations in AXIN2 gene as a risk factor for tooth agenesis and cancer: A review

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Authors

HLOUŠKOVÁ Alena BIELIK Peter BONCZEK Ondřej BALCAR Vladimír Josef ŠERÝ Omar

Year of publication 2017
Type Article in Periodical
Magazine / Source Neuroendocrinology Letters
MU Faculty or unit

Faculty of Science

Citation
Field ORL, ophthalmology, stomatology
Keywords hypodontia; oligodontia; Wnt signal pathway; beta-catenine; tankyrase
Description AXIN2 gene plays a crucial role in morphogenesis of craniofacial area and is essential for tooth development. AXIN2 gene is one of the most studied genes associated with tooth agenesis, the most common defect of dentition in humans. Polymorphic variants in AXIN2 gene are discussed in relation to the occurrence of the tooth agenesis but also as an indication of the risk of cancer. Mutations in AXIN2 gene were found in patients with colorectal or hepatocellular carcinoma, prostate cancer, ovarium or lung cancer. These findings support the hypothesis that missing teeth may be a significant marker for predisposition for cancer.
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