Evolution and functions of SMC complexes: new SMC5/6 insights

Authors	PALEČEK Jan GRUBER Stephan VONDROVÁ Lucie ADAMUS Marek ZÁBRADY Kateřina JURČIŠINOVÁ Lenka CRABBEN Saskia N van der HENNUS Marije P MCGREGOR Grant RITTER Deborah I LEHMANN Alan R OLIVER Antony W KOZLÍKOVÁ Barbora PLON Sharon E MURRAY Johanne M HAAFTEN Gijs van
Year of publication	2016
Citation
Description	The SMC (structure maintenance of chromosome) complexes are conserved from bacteria to humans (SMC/ScpAB and MukBEF in prokaryotes; cohesin, condensin and SMC5/6 in eukaryotes). They are critical for DNA replication, chromosome compaction and segregation, genome maintenance, and regulation of gene expression. We described marked structural similarities between bacterial SMC/ScpAB and eukaryotic SMC5/6 complexes (particularly their kite subunits). We discovered several important features of SMC5/6 kite subunits: their role in structural organization of the SMC5/6 complex, their DNA-binding ability, their evolution from bacteria to novel mammalian MAGE protein superfamily and new chromosome breakage syndrome associated with human Nse3-kite subunit mutations.
Related projects:	Úloha proteinu Nse, podjednotek komplexu SMC5/6, v procesech stabilizujících pozastavené replikacní vidlice Expressive Visualization of Protein Complexes