Anti-NMDAR encefalitida v dětském věku – kazuistika
| Title in English | Anti-NVDAR Encephalitis in Children - a Case Report |
|---|---|
| Authors | |
| Year of publication | 2017 |
| Type | Article in Periodical |
| Magazine / Source | Česká a slovenská neurologie a neurochirurgie |
| MU Faculty or unit | |
| Citation | |
| web | https://www.csnn.eu/en/journals/czech-and-slovak-neurology-and-neurosurgery/2017-2-3/anti-nmdar-encephalitis-in-children-a-case-report-60569?hl=cs |
| Doi | http://dx.doi.org/10.14735/amcsnn2017224 |
| Field | Neurology, neurosurgery, neurosciences |
| Keywords | limbic encephalitis; paraneoplastic antibodies; anti-NMDAR |
| Description | Autoimmune encephalitis is a rare condition of the central nervous system in children. In cases of primary involvement of the limbic system structures with corresponding clinical symptoms, we use the term limbic encephalitis. They occur as part of paraneoplastic symptoms or as autoimmune inflammation of the limbic system structures. The spectrum of non-specific symptoms can lead to misdiagnosis with improperly selected therapy and sequelae for the patient. We present a case of a 15-year-old patient with an autoimmune form of anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis. The primary manifestation was de novo epileptic paroxysmus with subacutely evolving and progressing qualitative impairment of consciousness. Aseptic inflammation in the cerebrospinal fluid led to a suspicion of infectious meningoencephalitis. Diagnosis of anti-NMDAR encephalitis was confirmed by the presence of antibodies in the cerebrospinal fluid and in the serum. Following acute deterioration of the condition, it was necessary to intensify therapy with corticosteroids, plasmapheresis, immunoglobulins, immunosuppressives and biological treatment. Despite complications, including impaired vital functions, the patient was cured without permanent sequelae. |
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