Human Treponema pallidum 11q/j isolate belongs to subsp. endemicum but contains two loci with a sequence in TP0548 and TP0488 similar to subsp. pertenue and subsp. pallidum, respectively

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Authors

MIKALOVÁ Lenka STROUHAL Michal OPPELT Jan GRANGE Philippe Alain JANIER Michel BENHADDOU Nadjet DUPIN Nicolas ŠMAJS David

Year of publication 2017
Type Article in Periodical
Magazine / Source PLoS neglected tropical diseases
MU Faculty or unit

Faculty of Medicine

Citation
Web http://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0005434
Doi http://dx.doi.org/10.1371/journal.pntd.0005434
Field Epidemiology, infectious diseases and clinical immunology
Keywords Treponema pallidum
Description The TEN 11q/j isolate was characterized using nested PCR followed by Sanger sequencing and/or direct Illumina sequencing. Altogether, 44 chromosomal regions were analyzed. Overall, the 11q/j isolate clustered with TEN strains Bosnia A and Iraq B as expected from previous TEN classification of the 11q/j isolate. However, the 11q/j sequence in a 505 bp-long region at the TP0488 locus was similar to Treponema pallidum subsp. pallidum (TPA) strains, but not to TEN Bosnia A and Iraq B sequences, suggesting a recombination event at this locus. Similarly, the 11q/j sequence in a 613 bp-long region at the TP0548 locus was similar to Treponema pallidum subsp. pertenue (TPE) strains, but not to TEN sequences.
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