Vitamin D receptor TaqI gene polymorphism and dental caries in Czech children
| Authors | |
|---|---|
| Year of publication | 2017 |
| Type | Article in Periodical |
| Magazine / Source | Caries Research |
| MU Faculty or unit | |
| Citation | |
| Doi | http://dx.doi.org/10.1159/000452635 |
| Field | ORL, ophthalmology, stomatology |
| Keywords | case-control study; dental caries; gene polymorphism; Gingivitis; Vitamin D receptor |
| Description | Aim: We analyzed the VDR TaqI (rs731236) gene polymorphism in children with and those without dental caries. Methods: A total of 388 subjects, 153 caries-free (with decayed/missing/filled teeth [DMFT] = 0) and 235 children with dental caries (DMFT >=1), were genotyped by the TaqMan method. Results: Although no significant differences in VDR TaqI allele and genotype frequencies between caries-free and caries-affected children were detected, a significant association between this polymorphism and gingivitis was found (p < 0.05). Conclusions: In contrast to previous studies from China and Turkey, the VDR TaqI gene variant cannot be used as a marker for identification of Czech children with increased dental caries risk. |
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