Toward Modelling and Analysis of Transient and Sustained Behaviour of Signalling Pathways
| Authors | |
|---|---|
| Year of publication | 2016 |
| Type | Article in Proceedings |
| Conference | Hybrid Systems Biology. HSB 2016 |
| MU Faculty or unit | |
| Citation | |
| Doi | http://dx.doi.org/10.1007/978-3-319-47151-8_4 |
| Field | Informatics |
| Keywords | signalling pathways; systems biology; parameter synthesis; dynamical systems; parameter estimation |
| Description | Signalling pathways provide a complex cellular information processing machinery that evaluates particular input stimuli and transfers them into the genome by means of regulation of specific genes expression. In this short paper, we provide a preliminary study targeting minimal models representing the topology of main signalling mechanisms. A special emphasis is given to distinguishing between monotonous (sustained) and non-monotonous (transient) time-course behaviour. A set of minimal parametrised ODE models is formulated and analysed in a workflow based on formal methods. |
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