The utility of -synuclein as biofluid marker in neurodegenerative diseases: a systematic review of the literature

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Authors	SIMONSEN Anja Hviid KUIPERIJ Bea EL-AGNAF Omar Mukhtar Ali ENGELBORGHS Sebastian HERUKKA Sanna-Kaisa PARNETTI Lucilla REKTOROVÁ Irena VANMECHELEN Eugeen KAPAKI Elisabeth VERBEEK Marcel MOLLENHAUER Brit
Year of publication	2016
Type	Article in Periodical
Magazine / Source	BIOMARKERS IN MEDICINE
MU Faculty or unit	Central European Institute of Technology
Citation
Web	http://www.futuremedicine.com/doi/10.2217/BMM.14.105
Doi	http://dx.doi.org/10.2217/BMM.14.105
Field	Neurology, neurosurgery, neurosciences
Keywords	alpha-synuclein; biomarker; CSF; diagnosis; ELISA; Parkinson's disease
Attached files	ZVV_2015_144_1337320_The_utility.xlsx ZVV_2016_004_1337320_The_utility.pdf
Description	The discovery of -synuclein (-syn) as a major component of Lewy bodies, neuropathological hallmark of Parkinson's disease (PD), dementia with Lewy bodies and of glial inclusions in multiple system atrophy initiated the investigation of -syn as a biomarker in cerebrospinal fluid (CSF). Due to the involvement of the periphery in PD the quantification of -syn in peripheral fluids such as serum, plasma and saliva has been investigated as well. We review how the development of multiple assays for the quantification of -syn has yielded novel insights into the variety of -syn species present in the different fluids; the optimal preanalytical conditions required for robust quantification and the potential clinical value of -syn as biomarker. We also suggest future approaches to use of CSF -syn in neurodegenerative diseases.
Related projects:	CEITEC - Central European Institute of Technology