Linking in Vitro Effects and Detected Organic Micropollutants in Surface Water Using Mixture-Toxicity Modeling

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Authors

NEALE Peta A. AIT-AISSA Selim BRACK Werner CREUSOT Nicolas DENISON Michael S. DEUTSCHMANN Bjoern HILSCHEROVÁ Klára HOLLERT Henner KRAUSS Martin NOVÁK Jiří SCHULZE Tobias SEILER Thomas-Benjamin SERRA Helene SHAO Ying ESCHER Beate I.

Year of publication 2015
Type Article in Periodical
Magazine / Source ENVIRONMENTAL SCIENCE & TECHNOLOGY
MU Faculty or unit

Faculty of Science

Citation
Web http://pubs.acs.org/doi/10.1021/acs.est.5b04083
Doi http://dx.doi.org/10.1021/acs.est.5b04083
Field Water pollution and control
Keywords ARYL-HYDROCARBON RECEPTOR; OXIDATIVE STRESS-RESPONSE; TREATMENT-PLANT EFFLUENTS; QUALITY TRIGGER VALUES; PREGNANE X RECEPTOR; WASTE-WATER; CHEMICAL-ANALYSIS; RISK-ASSESSMENT; CONCEPTUAL-FRAMEWORK; THYROID-HORMONE
Description Surface water can contain countless organic micropollutants, and targeted chemical analysis alone may only detect a small fraction of the chemicals present. Consequently, bioanalytical tools can be applied complementary to chemical analysis to detect the effects of complex chemical mixtures. In this study, bioassays indicative of activation of the aryl hydrocarbon receptor (AhR), activation of the pregnane X receptor (PXR), activation of the estrogen receptor (ER), adaptive stress responses to oxidative stress (Nrf2), genotoxicity (p53) and inflammation (NF-kappa B) and the fish embryo toxicity test were applied along with chemical analysis to water extracts from the Danube River. Mixture-toxicity modeling was applied to determine the contribution of detected chemicals to the biological effect. Effect concentrations for between 0 to 13 detected chemicals could be found in the literature for the different bioassays. Detected chemicals explained less than 0.2% of the biological effect in the PXR activation, adaptive stress response, and fish embryo toxicity assays, while five chemicals explained up to 80% of ER activation, and three chemicals explained up to 71% of AhR activation. This study highlights the importance of fingerprinting the effects of detected chemicals.
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