Decreased expression levels of PIWIL1, PIWIL2, and PIWIL4 are associated with worse survival in renal cell carcinoma patients
| Authors | |
|---|---|
| Year of publication | 2016 |
| Type | Article in Periodical |
| Magazine / Source | ONCOTARGETS AND THERAPY |
| MU Faculty or unit | |
| Citation | |
| Web | https://www.dovepress.com/decreased-expression-levels-of-piwil1-piwil2-and-piwil4-are-associated-peer-reviewed-fulltext-article-OTT |
| Doi | http://dx.doi.org/10.2147/OTT.S91295 |
| Field | Oncology and hematology |
| Keywords | kidney cancer; PIWIL; piRNA |
| Attached files | |
| Description | Piwi-interacting RNAs (piRNAs) are a newly discovered class of small non-coding RNAs involved in silencing of transposable elements and in sequence-specific chromatin modifications. PIWI proteins (PIWIL) belong to the family of Argonaute genes/proteins, bind piRNAs and their functioning have been described mainly in germ-line cells and more recently also in stem cells and cancer cells. There are four PIWI proteins PIWIL1, PIWIL2, PIWIL3, and PIWIL4 discovered in human till now. Recent studies suggested that deregulated the expression of Piwi proteins and selected piRNAs is common to many types of cancers. We found significantly lower expression of PIWIL1 (P<0.0001) and piR-823 (P=0.0001) in tumor tissue in comparison to paired renal parenchyma. Further, we observed progressive decrease in PIWIL1 (P=0.0228), PIWIL2 (P=0.0015), and PIWIL4 (P=0.0028) expression levels together with increasing clinical stage. PIWIL2 (P=0.0073) and PIWIL4 (P=0.0001) expression progressively decreased also with increasing Fuhrman grade. Most importantly, low-expression levels of PIWIL1 (P=0.009), PIWIL2 (P<0.0001), and PIWIL4 (P=0.0065) were significantly associated with worse overall survival in renal cell carcinoma (RCC) patients. Our results suggest the involvement of PIWIL genes and piR-823 in RCC pathogenesis, and indicate PIWIL1, PIWIL2, and PIWIL4 as potential prognostic biomarkers in patients with RCC. |
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